This research article presents a novel approach in the formulation and evaluation of a tablet in capsule device aimed at providing GI protection and effective pain management. Key aspects include the development of Aceclofenac Extended-Release tablets and Misoprostol Immediate Release tablets, enclosed in a hard gelatin capsule. The study covers preformulation, formulation development, in-process quality control checks, and stability studies. Results indicate the combination dosage form offers advantages in safety, patient compliance, and therapeutic efficacy.