Emerging drug resistance among pathogens is a growing threat to mankind. The rise of MDR strains of bacteria has generated a great challenge to treat infections caused by bacteria with the available antibiotics. For ages, the vast floral species of the mangrove ecosystem have been used for medicinal importance as they represent a valuable source of novel drug compounds although the chemistry and bioactivity of flora remain partly uninvestigated. Recently plant-derived therapeutic agents have gained an immense importance in the field of medical sciences for treating several health disorders and chronic diseases. An extensive literature is available on phytochemical profiling of mangroves but in this review an attempt was made to focus on latest findings of different mangrove species which have been reported for high phytochemical constituents with other biological activity.