Background: Behçet’s Disease (BD) is a variable vessel vasculitis that involves several organs and systems, causing ulcers on the oral, genital, and intestinal mucosa, skin lesions that are most commonly in the form of papules, pustules or nodules, arthritis, uveitis, central nervous system lesions, venous and arterial thrombosis and arterial aneurysms. Evoked potentials (EPs) are electrical potentials recorded over various parts of the nervous system in response to sensory or motor stimulation. Each evoked potential has a series of waves or peaks in response to the stimulus. Clinical evoked potentials performed in a clinical laboratory most often involve stimulation of one of the sensory systems and recording the evoked potentials from peripheral nerves, spinal cord, or brain. Three types of evoked potentials are routinely used in clinical practice: visual, auditory, and somatosensory. The importance of diagnosing optic neuritis (ON) in BD is challenging because of the possibility of reversible damage in early diagnosed patients. Otherwise, the prognosis is poor with permanent blindness. Visual Eps (VEP) may be used in BD to detect ON and sub clinical optic neuritis in patients with neurological involvement. The neurological symptoms of BD may have a relapsing and remitting course with multifocal involvement of the nervous system. Chronic CNS involvement with permanent deficits is not rare IN BD. Somatosensory Eps (SSEP) studies were valuable in monitoring BD activity or therapeutic response and disclosing subclinical CNS involvement.