Objective: It is important to recognize the broad range of clinical signs and symptoms associated with diabetes, as people with type 1 and type 2 diabetes are frequently misdiagnosed, ill-treated, or mismanaged. Therefore, the purpose of this study was to assess the prevalence of overall clinical presentation in patients with type 1 and type 2 diabetes. Methodology: This was a multicenter, cross- sectional study that was conducted using a non- probability sampling technique. The duration of the study was about six months, from January 1st, 2022, to June 30th, 2022. A total of 280 type 1 and type 2 diabetes patients, between the ages of 40 and 65 years, were included in the study. The socio- demographic parameters, such as age, gender, and socioeconomic status, health condition, comorbidities, and clinical symptoms associated with both types of diabetes, were documented. A chi square test was applied to evaluate the association between overall symptoms associated with both types. An independent t-test was applied to find out the association between means of demographic parameters. Results: The study findings showed that the mean ages of type 1 and type 2 diabetics were 52.80±14.75 and 52.96±15.98 years, respectively. The presence of renal and respiratory manifestations in type 1 and type 2 diabetes patients revealed a significant association in terms of frequent urination, nocturia, dyspnea grading, dyspnea severity, chest tightness, and severity of chest pain (p<0.05). Similarly, dermatological manifestations in diabetic patients revealed that the majority of type 2 diabetic patients, 113(80.7%) had dry, cracked skin; compared with type 1 diabetic patients, 71(50.7%), with a significant association observed between them (p<0.001). Conclusion: This study concluded that the majority of the dermatological, renal, respiratory, and neurological manifestations were highly prevalent in type 2 diabetes patients as compared to type 1 diabetes patients. Additionally, an individual's chance of getting type 1 and type 2 diabetes was increased by having comorbidities like dyslipidemia, hypertension, and obesity.