Background: The cerebellum is located at the anterior end of the hindbrain, the cerebellum, also known as the "little brain," is mostly recognized for its function in sensory motor processing. One of the most significant antiepileptic medications, valproic acid (VPA), has shown to be essential for pregnant epileptic patients in order to reduce the risk of convulsions for both the mothers and the foetuses. Omega-3 supplements were looked into as a potential preventative measure against a number of birth abnormalities. Its protection against VPA-induced cerebellar toxicity, however, was not adequately studied. We intended to provide an outline if Omega-3 have beneficial neuroprotective roles of the cerebellum. Conclusion: A persistent neurological condition called epilepsy is typified by frequent, erratic seizures that are caused by spikes in the brain's electrical activity. The information that is now available supports the possibility of using omega-3 fatty acids as a coadjuvant treatment in conjunction with anticonvulsant medications to treat epilepsy. Numerous studies have reported a preventive effect against cardiovascular disease as well as an increase in seizure thresholds and latency to seizures. To validate their therapeutic potential, more extensive human clinical studies are required as the majority of the data have come from animal models.