ISSN : 2663-2187

EFFECT OF ETHANOLIC EXTRACT OF MYRISTICA FRAGRANS SEEDS AND MUCUNA PRURIENS SEED EXTRACT ON INTERVENTION EFFECTS ON RATS GSH LEVEL IN BRAIN AND LIVER TISSUES

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Vikram Singh, Pankaj Masih, Dharmendra Singh Rajput, Naveen Gupt
ยป doi: 10.48047/AFJBS.6.6.2024.8260-8282

Abstract

This study investigates the intervention effects of ethanolic extracts from Myristica fragrans seeds and Mucuna pruriens seeds on glutathione (GSH) levels in the brain and liver tissues of rats. Myristica fragrans, commonly known as nutmeg, and Mucuna pruriens, also referred to as velvet bean, are renowned for their diverse pharmacological properties. Methods: Sprague-Dawley rats were divided into control and experimental groups. The experimental groups received ethanolic extracts of Myristica fragrans seeds and Mucuna pruriens seeds orally for a specified duration. GSH levels in brain and liver tissues were assessed using established biochemical assays. Results: The ethanolic extract of Myristica fragrans seeds exhibited a significant elevation in GSH levels in both brain and liver tissues compared to the control group. Similarly, Mucuna pruriens seed extract intervention demonstrated a notable increase in GSH levels in the brain and liver tissues of rats. Conclusion: The findings suggest that the ethanolic extracts of Myristica fragrans seeds and Mucuna pruriens seeds may exert antioxidant effects by enhancing GSH levels in the brain and liver tissues of rats. These interventions hold promise for further exploration in the context of neuroprotection and hepatic health, potentially contributing to novel therapeutic avenues.

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