ISSN : 2663-2187

EFFICIENT SYNTHESIS OF 1, 2, 4-TRIAZOLO [3, 4 -B]-1, 3, 4 -THIADIZOLES DERIVATIVES

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Vikas R Bhosale, Valmik S Kapase, Dhanesh P Gawari, Dinesh A Sasane, Kulbhushan A. Sasane
» doi: 10.33472/AFJBS.6.14.2024.2481-2488

Abstract

Derivatives of 3,6-disubstituted1,2,4-triazolo-[3,4-b]-1,3,4-thiadiazoles containing pyridine moiety was 4-Amino-5-pyridin-4-yl-4H-[1,2,4]triazole-3-thiol and 4-Amino-5-pyridin-3-yl-4H-[1,2,4] triazole-3-thiol synthesized by cyclization using substituted aromatic carboxylic acid in presence of POCl3. Derivatives of 3,6-disubstituted1,2,4-triazolo-[3,4-b]-1,3,4-thiadiazoles containing pyridine moiety was 4-Amino-5-pyridin-4-yl-4H-[1,2,4]triazole-3-thiol and 4-Amino-5-pyridin-3-yl-4H-[1,2,4] triazole-3-thiol synthesized by cyclization using substituted aromatic carboxylic acid in presence of POCl3.

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