Background: Assessment of computed tomography signs for suspected resistance identified in subjects with TB and performing timely drug-sensitivity testing in the laboratory could effectively shorten the diagnosis time for drug-resistant tuberculosis and make the early availability of the treatment along with treatment modifications in time to increase the therapeutic efficacy. Aim: To evaluate the imaging features in drug-sensitive and resistant pulmonary tuberculosis. Methods: The present study assessed 252 subjects from both genders where 52 subjects had drug-resistant tuberculosis and 250 subjects had drug-sensitive tuberculosis. In all the subjects CT findings were assessed and compared for results formulation. Results: Non-significant difference was seen in drug-sensitive and drug-resistant tuberculosis for a cavity with intermediate wall thickness, single cavity, consolidation, fibrosis, nodular infiltration, bronchiectasis, miliary pattern, pleural thickening, and pleural calcification with p=1.00, 0.614, 0.358, 0.186, 0.665, 0.086, 0.808, 0.578, and 0.469 respectively. Significantly higher multiple cavities were seen in 81% (n=42) subjects with p=0.001. Cavitary consolidation, thick-walled cavity, atelectasis, pleural effusion, and lymphadenopathy were significantly higher in subjects with drug-resistant tuberculosis with p=0.001, 0.001, 0.032, 0.015, and 0.001 respectively. Conclusions: The present study concludes that several cavities, particularly those with thick walls, in practically all lobes, notably the higher lobes, are highly suggestive of DR-TB.