Background: An accurate, precise, user-friendly, sensitive and validated spectrophotometric method has been developed for the estimation of moxifloxacin hydrochloride (MXF) in both pure form and dosage forms. In these methods N bromosuccinimide (NBS) is used as an environmentally friendly oxidizing agent in conjunction with three selected dyes: amaranth (AM), methylene blue (MB) and indigocarmine (IC). The methods employ excess amounts of NBS under acidic conditions to oxidize moxifloxacin hydrochloride. Using predetermined quantities of dyes AM, MB and IC the unreacted NBS is determined by reacting it chemically. Absorption was measured at 520 nm, 664 nm, 610 nm for AM, MB and IC dyes respectively. The analytical technique was implemented and validated by thoroughly examining and optimizing various factors that could potentially disrupt the reaction. Significant linear relationships, characterized by correlation coefficients ranging from 0.9993 to 0.9996, were observed under optimal conditions. These associations were valid within a concentration range of 1.0-18 µg/ml, 1.0-14 µg/ml, and 1.0-20 µg/ml respectively. AM method was found to have an LOD of 0.30 µg/ml while MB had an LOD of 0.29 µg/ml and IC had an LOD of 0.30 µg/ml. The accuracy and precision of the approaches' have been evaluated for measurements conducted within a single day as well as measurements conducted over multiple days. No significant interference was observed with the usual pill excipients. Besides, the suggested processes’ environmental impact was evaluated through three evaluation techniques specifically designed to measure environmental friendliness: the Analytical Greenness Metric (AGREE), the Green Analytical Procedure Index (GAPI) and Analytical Eco-Scale (AES). These assessments conclusively verified that the approaches have a diminished detrimental impact on the environment