The aim of present work was to formulate and evaluate extended release tablets of Tolbutamide using natural binders. Natural binders provides the tablet formulations with good hardness and friability. These binders prolongs the dissolution rate of some slightly soluble drugs and can be chosen as good candidate for sustained release. Tablets were prepared by direct compression method using different drug-polymer concentration. FT-IR study revealed that there was no chemical interaction between the drug and polymers used. Pre-compression and post-compression parameters complied with Pharmacopoeial limit for the tablets. Four different binders (tragacanth, gum acacia , guar gum, starch) were used in 3 different concentrations (25%, 50%, 75%) and was compared with the standard rate retardant polymer HPMC. The in vitro release study was performed and the results indicated that the formulation TEF8 (Guar Gum 50%) was found to be the optimized formulation which can extend the release up to a period of 24 hours. The kinetic release data showed that the optimized formulation followed zero order kinetics. From the stability studies it was clear that the formulation was stable after 2 months at accelerated condition of 40 °C±2 °C/75% RH±5% in a stability chamber.