ISSN : 2663-2187

IMMUNOMODULATOR ACTIVITY AND ANTI ARTHRITIC ACTIVITY OF SIDDHA POLYHERBAL FORMULATION MAHAANALURUVA CHOORANAM

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Dr.DHARANI .P ,Dr.SATHYANANDHINI .T ,Dr.U.CHITRA MD ,Dr.N.ANBU MD
ยป doi: 10.48047/AFJBS.6.15.2024.8247-8254

Abstract

Introduction: Mahaanaluruva chooranam (MAC) is a traditional herbal formulation from the siddha system of medicine. It is a polyherbal formulation, meaning a powder blend of several medicinal herbs, specifically used for treating various vaatha dosha imbalances. In siddha, vaatha dosha is associated with functions like movement, circulation, and breathing. Recent research suggests that MAC possess immunomodulatory activity, meaning it could influence the function of the immune system. This property could be beneficial in various ways, such as enhancing immune response and reducing inflammation. Chronic inflammatory conditions are often associated with an overactive immune system. MAC may help modulate the immune response and reduce inflammation. The immunomodulatory properties of MAC suggest its potential applications in a wider range of health conditions. Further scientific studies are needed to validate these claims and explore the mechanisms of action behind MAC's immunomodulatory effects. The study was conducted at CL Baid metha college of pharmacy, Chennai, Tamil Nadu. The study was done by using Wistar albino rats of either sex. The study evaluated MAC's impact on delayed-type hypersensitivity (DTH) using paw pad swelling. Rats receiving MAC at 100mg/kg and 200mg/kg showed increased paw swelling compared to the control group, suggesting a potential stimulation of the cellular immune response. The experiment assessed MAC's effectiveness against arthritis induced by Complete Freund's Adjuvant (CFA). Both MAC doses (100mg/kg and 200mg/kg) significantly reduced paw swelling compared to the untreated control group, indicating an anti-inflammatory effect. The results were comparable to the standard drug, indomethacin. Therefore, the study concludes that Mahaanaluruva chooranam has significant immunomodulator activity which will be helpful for autoimmune diseases like rheumatoid arthritis.

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