Background: Breast cancer is the most prevalent cancer among females all over the world. Breast self-examination (BSE), mammography, and clinical breast examination are screening methods used to detect breast cancer early. Aim of the study: the aim of this study was toImprove breast cancer preventive behaviour among female nursing students. Subjects and Methods: Research Design:Aquazi -experimental design with pre/ post assessment was used in the current studySetting : The study was conducted at Technical Nursing Institute at Zagazig University, Zagazig city at Elsharkia Governorate . Subjects: the data was collected from180 female students during the academic year 2022-2023. Tools of data collection: three types of tools were used for data collection (1) An interview questionnaire (2) student's Knowledge regarding breast cancer and breast self-examination, (3) Breast self-examination observational check list. Results: revealed that The mean age of students was 18.63±0.723yearsold, there was highly statistically significant differenceof studied female student's knowledge regarding breast self-examination between pre/ post-intervention (P= 0.000**), while there was no statistically significant difference between post/ follow up intervention (P >0.05).the present study demonstrated that (20.6%) of studied female students had good knowledge about breast cancer at pre intervention phase, while this percentage increased to 88.3%& 80.0% respectively, at post and follow up intervention. . Concerning level of total practice,93.3 % of female students showed unsatisfactory level of practice pre-program compared to 91.7 %,78.3%of them have satisfactory level of practice immediately post intervention and one month post program respectively. Conclusion: The results of present study supported the research hypothesis that there is marked an improvement in knowledge, practice toward breast cancer compared to before applying educational intervention Recommendations: Continuing breast cancer preventive program for students to improve their knowledge. Several instructional handout &brochures should be distributed to female students containing preventive measures of BC &steps of BSE