Background: Overweight/obesity is considered a common comorbidity in both children and adults with epilepsy. Seizure is a transient abnormal excessive hyper synchronous neuronal activity in the brain. It can present as a paroxysmal alteration of neurological function, disturbance of consciousness, behavioral changes, cognition, emotion, motor or sensory dysfunction.The inflammation is a biological response of the immune system that can be triggered by various factors, including pathogens, damaged cells, and toxic compounds. Inflammation is a conserved evolutionary process characterized by the activation of immune and non-immune cells that protect the host from bacteria, viruses, toxins, and infections by eliminating pathogens and promoting tissue repair and restoration The aim of the present study was to review the role of serum level of interleukin-6 and body mass index in adult epileptic patients