Volume 7 | Issue -2
Volume 7 | Issue -2
Volume 7 | Issue -2
Volume 7 | Issue -2
Volume 7 | Issue -2
The search for new sources of biologically active substances (BAS) and methods of obtaining safe antimicrobial plant preparations is a relevant direction of modern pharmacology and biotechnology. This study aimed to determine the most effective method for obtaining aqueous extracts of Tagetes patula L. flowers with antimicrobial properties. HPLC results showed that the highest content of BAS was characteristic for aqueous extracts obtained by boiling for 60 minutes (they contained the most luteolin and quercetin derivatives, quercetin itself, and protocatecholic acid, as well as rutin and ellagic acid). The maximum yield of gallic acid was observed in the extracts obtained by infusion with stirring. The aqueous extracts of T. patula flowers, obtained by boiling for 30 and 60 minutes, respectively, exhibited the greatest antimicrobial activity against both E. coli and S. aureus, while the diameter of the lysis zone increased in proportion to the duration of extraction, with the exception of the interval of 30-60 minutes for E. coli. The antimicrobial effect was more pronounced against E. coli than against S. aureus. Thus, T. patula aqueous extracts have potential applications for as medicines, natural pesticides, siderates, and feed additives.