Volume 7 | Issue -2
Volume 7 | Issue -2
Volume 7 | Issue -2
Volume 7 | Issue -2
Volume 7 | Issue -2
Background: Pre-eclampsia leads to maternal and fetal death. Early discovery improves results, however existing diagnostic procedures generally fail to forecast the condition's beginning. The urine calcium-creatinine ratio (UCCR) may be a non-invasive diagnostic for pre-eclampsia identification due to abnormal calcium metabolism in afflicted pregnancies. Aim: To investigate the predictive value of UCCR as a biomarker for the early detection of pre-eclampsia in pregnant women. Methods: A prospective cohort study comprised one hundred expectant mothers. Pre-eclampsia was watched for in the participants. Samples of urine were collected at 20 and 24 weeks to assess UCCR. Up to delivery, participants' pre-eclampsia was observed. The ROC analysis was utilised to assess the predictive accuracy of the UCCR after its sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were computed. Results: The average age and weight of the study population were 26.47 years (±5.26) and 62.66 kg (±5.34), respectively. 92% of participants lived in cities, and 82% of them were primigravidae. For 91% of the women, vaginal birth was the usual mode of delivery. The UCCR values of women with pre-eclampsia were substantially lower than those of non-eclamptic women (p < 0.001). An Area Under the Curve (AUC) of 0.961 was shown by the ROC analysis, suggesting strong prediction accuracy. With a positive predictive value of 29.4% and a negative predictive value of 100%, the ideal UCCR cut-off value of 0.0650 produced a sensitivity of 100% and a specificity of 73.3%. Conclusion: UCCR is a promising non-invasive biomarker for the early detection of pre-eclampsia, with high sensitivity and NPV. However, its moderate specificity suggests it should be used alongside other clinical assessments. Recommendations: Further large-scale studies are recommended to validate the UCCR cut-off values and refine its use in clinical practice, potentially integrating it into routine antenatal screening protocols for early intervention.