Oral cancer has become one of the most prevalent types of cancer in Southeast Asia, with consistently high rates being reported due to the high prevalence of tobacco use in this region. This review aims to provide an update regarding the age-standardized incidence and mortality rates for the 11 countries of this region by studying the trends and annual percentage changes of oral cancer incidence rates during the past decade concerning the changing percentages of tobacco use among the population residing in these countries. The rates were collected from the Global Cancer Observatory, and each country's annual percentage change was calculated using Joinpoint regression analysis software. Generally, the decreasing trend of oral cancer was observed nationally and regionally in Southeast Asia. However, the rates in Cambodia and Thailand remain on the rise.