Background: For the last two decades, numerous work fields have been developed, two of those fields are artificial intelligence (AI) and machine learning (ML). In both medicine and dentistry fields there have been several applications of AI and ML. However, despite encouraging results, its application in the treatment of irregularities in the teeth (orthodontics) has developed slowly. The current body of literature on AI and machine learning applications in orthodontics has received insufficient notice and evaluation. This is unfortunate since Orthodontics with its inherent focus on patterns, models and predictions is in prime position to reap the benefits of AI and ML. Advances in AI are not limited to just theories and models, they offer much needed clinical insights that further empower both expert and novice practitioner. AI also provides important heuristics in areas that have been traditionally contentious for Orthodontists, such as decisions of extractions and Orthognathic surgery. The findings of this review herald the most recent advances of AI in multiple facets of Orthodontics. From diagnosis to treatment planning and visualization to assessment of debatable subjects like beauty and growth prediction Aim: This brief review article intends to provide the orthodontics dentists with a knowledge of both AI and ML and their applications.