A validated, sensitive, precise, and dependable spectrophotometric technique has been developed to accurately detect the concentration of moxifloxacin hydrochloride in pure and dosage forms. The methods utilise ceric(IV) ammonium sulfate (Ce(IV)) as an oxidising agent and 3 specific dyes: indigocarmine (IC), rhodamine B (RB) and orange G (OG). The ways depend on the oxidation process of moxifloxacin hydrochloride using a plentiful quantity of ceric(IV) ammonium sulfate in acidic circumstances. The residual ceric(IV) ammonium sulfate is measured by subjecting it to a chemical reaction with preset amounts of dyes, IC, RB, and OG. The absorbance is measured at λmax of 610, 550 and 478 nm for IC, RB, and OG dye, respectively. The analytical technique was implemented and validated by thoroughly examining and optimizing various factors that could potentially disrupt the reaction. Significant linear relationships, characterized by correlation coefficients ranging from 0.9990 to 0.9997, were observed under optimal conditions. These associations remained consistent throughout concentration ranges of 1.0-8.0, 1.0-10, and 1.0-15 µg/ml. The limits of detection (LOD) of 0.29, 0.30, and 0.30 µg/ml for IC, RB, and OG methods, respectively. The calculated molar absorptivity values are 2.8262 × 104, 1.8855 × 104 and 1.4717 × 104 L.mol-1.cm-1 using IC, RB, and OG methods, respectively. The accuracy and precision of the approaches' have been evaluated for measurements conducted within a single day as well as measurements conducted over multiple days. The methods were successfully applied to the assay of moxifloxacin hydrochloride in tablets and the results were statistically compared with those of the reference method by applying Student’s t-test and F-test. No significant interference was observed with the usual pill excipients